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1

Plerixafor Plus Granulocyte Colony-Stimulating Factor versus Placebo Plus Granulocyte Colony-Stimulating Factor for Mobilization of CD34+ Hematopoietic Stem Cells in Patients with Multiple Myeloma and Low Peripheral Blood CD34+ Cell Count: Results of a Subset Analysis of a Randomized Trial

Nademanee, Auayporn P., DiPersio, John F., Maziarz, Richard T., Stadtmauer, Edward A., Micallef, Ivana N., Stiff, Patrick J., Hsu, Frank J., Bridger, Gary, Bolwell, Brian J.

Journal:

Biology of Blood and Marrow Transplantation

Year:

2012

Language:

english

File:

PDF, 588 KB

english, 2012

2

ChemInform Abstract: Regioselective Synthesis of Aryl Hydrazides by Palladium-Catalyzed Coupling of t-Butylcarbazate with Substituted Aryl Bromides.

Zhongren Wang, Renato T. Skerlj, Gary J. Bridger

Journal:

Year:

1999

File:

PDF, 29 KB

1999

3

ChemInform Abstract: Bicyclam Derivatives as HIV Inhibitors

Gary J. Bridger, Renato T. Skerlj

Journal:

Year:

2000

File:

PDF, 23 KB

2000

4

ChemInform Abstract: Facile Cyanomethylation of Bromopyridines by Nucleophilic Substitution with Lithioacetonitrile.

Renato T. Skerlj, David Bogucki, Gary J. Bridger

Journal:

Year:

2001

File:

PDF, 30 KB

2001

5

ChemInform Abstract: Palladium(0)-Catalyzed Coupling of Organozinc Iodide Reagents with Bromopyridines: Synthesis of Selectively Protected Pyridine-Containing Azamacrocycles.

Renato T. Skerlj, Yuanxi Zhou, Trevor Wilson, Gary J. Bridger

Journal:

Year:

2002

File:

PDF, 33 KB

2002

6

Facile Synthesis of a Selectivity Protected Triazamacrocycle.

Renato T. Skerlj, Siqiao Nan, Yuanxi Zhou, Gary J. Bridger

Journal:

Year:

2003

File:

PDF, 136 KB

2003

7

Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines.

Krystyna A. Skupinska, Ernest J. McEachern, Renato T. Skerlj, Gary J. Bridger

Journal:

Year:

2003

File:

PDF, 207 KB

2003

8

RuIII Complexes of Edta and Dtpa Polyaminocarboxylate Analogues and Their Use as Nitric Oxide Scavengers

Tim Storr, Beth R. Cameron, Robert A. Gossage, Helen Yee, Renato T. Skerlj, Marilyn C. Darkes, Simon P. Fricker, Gary J. Bridger, Nathan A. Davies, Michael T. Wilson, Kevin P. Maresca, Jon Zubieta

Journal:

European Journal of Inorganic Chemistry

Year:

2005

Language:

english

File:

PDF, 232 KB

english, 2005

9

Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication

Renato Skerlj, Gary Bridger, Ernie McEachern, Curtis Harwig, Chris Smith, Trevor Wilson, Duane Veale, Helen Yee, Jason Crawford, Krystyna Skupinska, Rossana Wauthy, Wen Yang, Yongbao Zhu, David Boguck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

10

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

Renato Skerlj, Gary Bridger, Ernest McEachern, Curtis Harwig, Chris Smith, Alan Kaller, Duane Veale, Helen Yee, Krystyna Skupinska, Rossana Wauthy, Letian Wang, Ian Baird, Yongbao Zhu, Kate Burrage, W

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 442 KB

english, 2011

11

Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication

Renato Skerlj, Gary Bridger, Yuanxi Zhou, Elyse Bourque, Jonathan Langille, Maria Di Fluri, David Bogucki, Wen Yang, Tongshuang Li, Letian Wang, Susan Nan, Ian Baird, Markus Metz, Marilyn Darkes, Jean

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.34 MB

english, 2011

12

Effects of AMD3100 on transmigration and survival of acute myelogenous leukemia cells

Jane L. Liesveld, Jeremy Bechelli, Karen Rosell, Chaohui Lu, Gary Bridger, Gordon Phillips II, Camille N. Abboud

Journal:

Leukemia Research

Year:

2007

Language:

english

File:

PDF, 1.06 MB

english, 2007

13

Receptors for uric acids. 2. A cautionary observation

T.Ross Kelly, Mark T. Bilodeau, Gary J. Bridger, Chen Zhao

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 330 KB

english, 1989

14

Facile synthesis of a selectively protected triazamacrocycle

Renato T. Skerlj, Siqiao Nan, Yuanxi Zhou, Gary J. Bridger

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 108 KB

english, 2002

15

Regioselective synthesis of aryl hydrazides by palladium-catalyzed coupling of t-butylcarbazate with substituted aryl bromides

Zhongren Wang, Renato T. Skerlj, Gary J. Bridger

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 207 KB

english, 1999

16

Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro

Coralie Martin, Gary J. Bridger, Sara M. Rankin

Journal:

British Journal of Haematology

Year:

2006

Language:

english

File:

PDF, 125 KB

english, 2006

17

The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding

Karen De Vreese, Diane Reymen, Philip Griffin, Alexander Steinkasserer, Gudrun Werner, Gary J. Bridger, José Esté, William James, Geoffrey W. Henson, Jan Desmyter, Jozef Anné, Erik De Clercq

Journal:

Antiviral Research

Year:

1996

Language:

english

File:

PDF, 776 KB

english, 1996

18

Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1

JoséA. Esté, Karen De Vreese, Myriam Witvrouw, Jean-Claude Schmit, Anne-Mieke Vandamme, Jozef Anné, Jan Desmyter, Geoffrey W. Henson, Gary Bridger, Erik De Clercq

Journal:

Antiviral Research

Year:

1996

Language:

english

File:

PDF, 739 KB

english, 1996

19

AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

Sigrid Hatse, Katrien Princen, Erik De Clercq, Mette M. Rosenkilde, Thue W. Schwartz, Pedro E. Hernandez-Abad, Renato T. Skerlj, Gary J. Bridger, Dominique Schols

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 341 KB

english, 2005

20

Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication

Renato Skerlj, Gary Bridger, Yuanxi Zhou, Elyse Bourque, Ernest McEachern, Jonathan Langille, Curtis Harwig, Duane Veale, Wen Yang, Tongshong Li, Yongbao Zhu, Michael Bey, Ian Baird, Michael Sartori,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

21

The CXCR4 antagonist AMD3100 releases a subset of G-CSF-primed peripheral blood progenitor cells with specific gene expression characteristics

Stefan Fruehauf, Timon Seeger, Patrick Maier, Li Li, Stephan Weinhardt, Stephanie Laufs, Wolfgang Wagner, Volker Eckstein, Gary Bridger, Gary Calandra, Frederick Wenz, W. Jens Zeller, Hartmut Goldschm

Journal:

Experimental Hematology

Year:

2006

Language:

english

File:

PDF, 211 KB

english, 2006

22

The therapeutic potential in targeting CCR5 and CXCR4 receptors in infectious and allergic pulmonary disease

Cory M. Hogaboam, Kristin J. Carpenter, Jane M. Schuh, Amanda A.E.I. Proudfoot, Gary Bridger, Karen F. Buckland

Journal:

Pharmacology & Therapeutics

Year:

2005

Language:

english

File:

PDF, 1.19 MB

english, 2005

23

HIV-1 entry inhibition by small-molecule CCR5 antagonists: A combined molecular modeling and mutant study using a high-throughput assay

Jean Labrecque, Markus Metz, Gloria Lau, Marilyn C. Darkes, Rebecca S.Y. Wong, David Bogucki, Bryon Carpenter, Gang Chen, Tongshuang Li, Susan Nan, Dominique Schols, Gary J. Bridger, Simon P. Fricker,

Journal:

Year:

2011

Language:

english

File:

PDF, 1.55 MB

english, 2011

24

Increased matrix metalloproteinase activity after canine cardiopulmonary bypass is suppressed by a nitric oxide scavenger

Irvin Mayers, Thomas Hurst, Anna Radomski, David Johnson, Simon Fricker, Gary Bridger, Beth Cameron, Marilyn Darkes, Marek W. Radomski

Journal:

The Journal of Thoracic and Cardiovascular Surgery

Year:

2003

Language:

english

File:

PDF, 123 KB

english, 2003

25

The orally bioavailable allosteric CXCR4 HIV-1 entry inhibitor AMD11070

Fricker, Simon, Mosi, Renee, Anastassova, Virginia, Labrecque, Jean, Wong, Rebecca, Skerlj, Renato, Bridger, Gary, Huskens, Dana, Schols, Dominique

Journal:

Year:

2012

Language:

english

File:

PDF, 74 KB

english, 2012

26

Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines

Skupinska, Krystyna A., McEachern, Ernest J., Skerlj, Renato T., Bridger, Gary J.

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 112 KB

english, 2002

27

Synthesis and Structure−Activity Relationships of Azamacrocyclic C-X-C Chemokine Receptor 4 Antagonists: Analogues Containing a Single Azamacrocyclic Ring are Potent Inhibitors of T-Cell Tropic (X4) HIV-1 Replication

Bridger, Gary J., Skerlj, Renato T., Hernandez-Abad, Pedro E., Bogucki, David E., Wang, Zhongren, Zhou, Yuanxi, Nan, Susan, Boehringer, Eva M., Wilson, Trevor, Crawford, Jason

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.80 MB

english, 2010

28

Successful Stem Cell Remobilization Using Plerixafor (Mozobil) Plus Granulocyte Colony-Stimulating Factor in Patients with Non-Hodgkin Lymphoma: Results from the Plerixafor NHL Phase 3 Study Rescue Protocol

Ivana N. Micallef, Patrick J. Stiff, John F. DiPersio, Richard T. Maziarz, John M. McCarty, Gary Bridger, Gary Calandra

Journal:

Biology of Blood and Marrow Transplantation

Year:

2009

Language:

english

File:

PDF, 234 KB

english, 2009

29

Transplanted CD34+ Cell Dose Is Associated with Long-Term Platelet Count Recovery following Autologous Peripheral Blood Stem Cell Transplant in Patients with Non-Hodgkin Lymphoma or Multiple Myeloma

Patrick J. Stiff, Ivana Micallef, Auayporn P. Nademanee, Edward A. Stadtmauer, Richard T. Maziarz, Brian J. Bolwell, Gary Bridger, Sachin Marulkar, Frank J. Hsu, John F. DiPersio

Journal:

Biology of Blood and Marrow Transplantation

Year:

2011

Language:

english

File:

PDF, 151 KB

english, 2011

30

AMD3100, a CxCR4 Antagonist, Attenuates Allergic Lung Inflammation and Airway Hyperreactivity

Nicholas W. Lukacs, Aaron Berlin, Dominique Schols, Renato T. Skerlj, Gary J. Bridger

Journal:

The American Journal of Pathology

Year:

2002

Language:

english

File:

PDF, 824 KB

english, 2002

31

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4

Sigrid Hatse, Katrien Princen, Gary Bridger, Erik De Clercq, Dominique Schols

Journal:

Year:

2002

Language:

english

File:

PDF, 378 KB

english, 2002

32

Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

Sigrid Hatse, Katrien Princen, Kurt Vermeire, Lars-Ole Gerlach, Mette M. Rosenkilde, Thue W. Schwartz, Gary Bridger, Erik De Clercq, Dominique Schols

Journal:

Year:

2003

Language:

english

File:

PDF, 497 KB

english, 2003

33

99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside GD2-positive tumors

Rosa Fonti, Nai-Kong V Cheung, Gary J Bridger, Hong-Fen Guo, Michael J Abrams, Steven M Larson

Journal:

Nuclear Medicine and Biology

Year:

1999

Language:

english

File:

PDF, 303 KB

english, 1999

34

Chemokines Acting via CXCR2 and CXCR4 Control the Release of Neutrophils from the Bone Marrow and Their Return following Senescence

Coralie Martin, Peter C.E Burdon, Gary Bridger, Jose-Carlos Gutierrez-Ramos, Timothy J Williams, Sara M Rankin

Journal:

Year:

2003

Language:

english

File:

PDF, 428 KB

english, 2003

35

AMD3465, a Novel CXCR4 Receptor Antagonist, Abrogates Schistosomal Antigen-Elicited (Type-2) Pulmonary Granuloma Formation

Jerry S. Hu, Christine M. Freeman, Valerie R. Stolberg, Bo Chin Chiu, Gary J. Bridger, Simon P. Fricker, Nicholas W. Lukacs, Stephen W. Chensue

Journal:

The American Journal of Pathology

Year:

2006

Language:

english

File:

PDF, 702 KB

english, 2006

36

Bisubstrate reaction templates. Examination of the consequences of identical versus different binding sites

Kelly, T. Ross, Bridger, Gary J., Zhao, Chen

Journal:

Journal of the American Chemical Society

Year:

1990

Language:

english

File:

PDF, 1.47 MB

english, 1990

37

Merkel cell tumor of the skin

Gary P. Kaplan, Michael J. Bookbinder, Douglas R. Hood, Samuel L. Bridgers

Journal:

Human Pathology

Year:

1988

Language:

english

File:

PDF, 130 KB

english, 1988

38

Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication

Skerlj, Renato T., Bridger, Gary J., Kaller, Al, McEachern, Ernest J., Crawford, Jason B., Zhou, Yuanxi, Atsma, Bem, Langille, Jonathon, Nan, Susan, Veale, Duane, Wilson, Trevor, Harwig, Curtis, Hatse

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.10 MB

english, 2010

39

Practical Convergent Laboratory-Scale Synthesis of a CCR5 Receptor Antagonist

Crawford, Jason B., Chen, Gang, Carpenter, Bryon, Wilson, Trevor, Ji, Jenny, Skerlj, Renato T., Bridger, Gary J.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 928 KB

english, 2012

40

Design of Substituted Imidazolidinylpiperidinylbenzoic Acids as Chemokine Receptor 5 Antagonists: Potent Inhibitors of R5 HIV-1 Replication

Skerlj, Renato, Bridger, Gary, Zhou, Yuanxi, Bourque, Elyse, McEachern, Ernest, Metz, Markus, Harwig, Curtis, Li, Tong-Shuang, Yang, Wen, Bogucki, David, Zhu, Yongbao, Langille, Jonathan, Veale, Duane

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 772 KB

english, 2013

41

THE THYROID HORMONE

Nademanee, Auayporn P., DiPersio, John F., Maziarz, Richard T., Stadtmauer, Edward A., Micallef, Ivana N., Stiff, Patrick J., Hsu, Frank J., Bridger, Gary, Bolwell, Brian J.

Journal:

Year:

1952

Language:

english

File:

PDF, 405 KB

english, 1952

42

Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist

Hübel, Kai, Liles, W. Conrad, Broxmeyer, Hal E., Rodger, Elin, Wood, Brent, Cooper, Scott, Hangoc, Giao, MacFarland, Ron, Bridger, Gary J., Henson, Geoffrey W., Calandra, Gary, Dale, David C.

Journal:

Supportive Cancer Therapy

Year:

2004

Language:

english

File:

PDF, 149 KB

english, 2004

43

Spontaneous Enzymatically Mediated Dynamic Kinetic Resolution of 8-Amino-5,6,7,8-tetrahydroquinoline

Crawford, Jason B., Skerlj, Renato T., Bridger, Gary J.

Journal:

Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 63 KB

english, 2007

44

A Versatile Intermediate for the Preparation of C-Functionalized Azamacrocycles and Application to the Synthesis of the Potent Anti-HIV Agent (±)JM2936

Bridger, Gary J., Skerlj, Renato T., Padmanabhan, Sreenivasan, Thornton, David

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 176 KB

english, 1996

45

N-Terminus Urea-Substituted Chemotactic Peptides: New Potent Agonists and Antagonists toward the Neutrophil fMLF Receptor

Higgins, John D., Bridger, Gary J., Derian, Claudia K., Beblavy, Michael J., Hernandez, Pedro E., Gaul, Forrest E., Abrams, Michael J., Pike, Marilyn C., Solomon, Howard F.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 83 KB

english, 1996

46

Metal Ion Enhanced Binding of AMD3100 to Asp 262 in the CXCR4 Receptor †

Gerlach, Lars Ole, Jakobsen, Janus S., Jensen, Kasper P., Rosenkilde, Mette R., Skerlj, Renato T., Ryde, Ulf, Bridger, Gary J., Schwartz, Thue W.

Journal:

Year:

2003

Language:

english

File:

PDF, 329 KB

english, 2003

47

Selective Inhibition of N -Formylpeptide-Induced Neutrophil Activation by Carbamate-Modified Peptide Analogues †

Derian, Claudia K., Solomon, Howard F., Higgins, John D., Beblavy, Michael J., Santulli, Rosemary J., Bridger, Gary J., Pike, Marilyn C., Kroon, Daniel J., Fischman, Alan J.

Journal:

Year:

1996

Language:

english

File:

PDF, 272 KB

english, 1996

48

Ruthenium(III) Polyaminocarboxylate Complexes: Efficient and Effective Nitric Oxide Scavengers

Cameron, Beth R., Darkes, Marilyn C., Yee, Helen, Olsen, Micki, Fricker, Simon P., Skerlj, Renato T., Bridger, Gary J., Davies, Nathan A., Wilson, Michael T., Rose, David J., Zubieta, Jon

Journal:

Inorganic Chemistry

Year:

2003

Language:

english

File:

PDF, 164 KB

english, 2003

49

A bisubstrate reaction template

Kelly, T. Ross, Zhao, Chen, Bridger, Gary J.

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 255 KB

english, 1989

50

Synthesis and Structure-Activity Relationships of Phenylenebis(methylene)-Linked Bis-Tetraazamacrocycles That Inhibit HIV Replication. Effects of Macrocyclic Ring Size and Substituents on the Aromatic Linker

Bridger, Gary J., Skerlj, Renato T., Thornton, David, Padmanabhan, Sreenivasan, Martellucci, Stephen A., Henson, Geoffrey W., Abrams, Michael J., Yamamoto, Naohiko, Vreese, Karen De

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.66 MB

english, 1995

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